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Immunopharmacology 1993 Sep;26(2):
139-146
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Activation of peritoneal
macrophages by polysaccharopeptide from the mushroom, Coriolus versicolor. |
Liu WK, Ng TB, Sze SF, Tsui
KW
Department of Anatomy, Faculty
of Medicine, Chinese University of Hong Kong, Shatin.
| Polysaccharopeptide (PSP) is a substance
produced by an edible mushroom, Coriolus versicolor which has
been claimed to possess antitumor activity. However, neither
tumoricidal activity nor cytotoxicity was observed when five
tumor cell lines and mouse peritoneal macrophages were cultured
in vitro in the presence of 2.5-10 micrograms/ml PSP. An increase
in the production of reactive nitrogen intermediates, reactive
oxygen intermediates (superoxide anions) and tumor necrosis
factor was measured in peritoneal macrophages collected from
inbred C57 mice which had received PSP in the drinking
water for 2 weeks. Northern blot analysis also demonstrated that
PSP activated the transcription of tumor necrosis factor gene in
these cells, indicating that PSP exerted an immunomodulatory
effect on the defensive cells. |
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