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Cancer Biother 1994;9(1):55-62
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Oxidative stress relief for cancer-bearing
hosts by the protein-bound polysaccbaride of Coriolus versicolor
QUEL with SOD mimicking activity. |
Kobayashi Y, Kariya K, Saigenji K, Nakamura K
Molecular Biology Laboratory, Kitasato
University School of Medicine, Kanagawa, Japan.
| The protein-bound polysaccharide of Coriolus versicolor QUEL
(PS-K) expresses the mimetic activity of superoxide dismutase
(SOD). Human cancer patients usually suffer from oxidative stress
(OS). Examination was made to determine the capacity of this drug
with SOD mimetic activity for relieving os. Rats
transplanted with Walker 256 fibrosarcoma showed OS on day
12. After confirming high levels of OS on day 13, PS-K50 mg/kg
was intraperitoneally administered, and prompt decrease in
O2-release from RBC was noted. The drug ceased to have any effect
24 hours following the first inoculation. Average OS in human
cancer patients was found twice that in healthy persons. In human
cancer patients perorally administered PS-K3.O g/day, OS
decreased to the normal level one day after the initial
administration. Plasma lipid peroxide (LPO) in cancer patients
treated with PS-K for 28 days increased and withdrawal of the
drug led to decreased LPO. |
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